Blaschko's lines

Blaschko's lines, also called the Lines of Blaschko, are skin lines invisible under normal conditions. They become apparent when some diseases of the skin or mucosa manifest themselves according to these patterns. They follow a "V" shape over the back, "S" shaped whorls over the chest, stomach, and sides, and wavy shapes on the head.[1]

The lines are believed to trace the migration of embryonic cells.[2][3] The stripes are a type of genetic mosaicism.[4] They do not correspond to nervous, muscular, or lymphatic systems. The lines can be observed in other animals such as cats and dogs.[5][6]

German dermatologist Alfred Blaschko is credited for the first demonstration of these lines in 1901.[7]

Contents

Conditions distributed along Blaschko's lines

The skin lesions that follow the Blaschko's lines are varied. They include genetic, congenital and acquired (i.e. non-genetic) conditions.[8] Examples include:

See also

References

  1. ^ Brown, Philip M. (2002). Transcription. CRC Press. p. 38. ISBN 9780415272001. http://books.google.com/?id=MWdS56hbkbEC&pg=PA38&dq=%22blaschko%27s+lines%22. 
  2. ^ Harper, John. Textbook of Pediatric Dermatology. p. 691. ISBN 0865429391. http://books.google.com/?id=z0PEdterBCwC&pg=PA691&dq=%22blaschko%27s+lines%22year=2000. 
  3. ^ Ruggieri, Martino (2008). Neurocutaneous Disorders: Phakomatoses & Hamartoneoplastic Syndromes. Springer. p. 569. ISBN 9783211213964. http://books.google.com/?id=b1NI28tR4hIC&pg=PA569&dq. 
  4. ^ Roach, Ewell S. (2004). Neurocutaneous Disorders. Cambridge University Press. p. 98. ISBN 9780521781534. http://books.google.com/?id=-kEYmZs-csgC&pg=PA98&dq=%22blaschko%27s+lines%22. 
  5. ^ Muller, George and Kirk, Robert (2001). Muller & Kirk's small animal dermatology. Elsevier Health Sciences. p. 9. ISBN 9780721676180. http://books.google.com/?id=aK2XZdCiwdwC&pg=PA9&dq=%22blaschko%27s+lines%22. 
  6. ^ Gross, Thelma Lee (2004). Veterinary Dermatopathology. Wiley-Blackwell. p. 156. ISBN 9780632064526. http://books.google.com/?id=VKa2Wo3Wc-kC&pg=PA156&dq=%22blaschko%27s+lines%22. 
  7. ^ Blaschko, Alfred (1901). Die Nervenverteilung in der Haut in ihre Beziehung zu den Erkrankungen der Haut. 
  8. ^ Bolognia J L, Orlow S J, Gilick S G (1994). "Lines of Blaschko". Journal of the American Academy of Dermatology 31 (2): 157–190. doi:10.1016/S0190-9622(94)70143-1. PMID 8040398. 

External links